Your subscription could not be saved. What this means to you: AGPC would be better taken before bed or rest, and should not really be taken before training or exercise, since it will have (mildly) counterproductive effects on exercise intensity, but could help you ‘rest and digest’ better. What this means to you: Dopamine is hugely important in terms of motivation, desire, pleasure, satisfaction and ‘zest’ for life, etc. Alpha GPC for example increases dopamine concentrations in certain areas of the brain, while Citicoline affects the release of dopamine and the densities of the dopamine receptors.. When levels are low, thoughts can be sluggish, forming new memories or accessing old memories can be difficult, and you may experience “brain fog.”. If you are NOT supplementing with PC, then the use of CDP choline might augment the production of PC (PC is a very ‘healthful’ compound, with several important functions in the nervous system). Just like Alpha GPC, CDP choline has been shown to be well tolerated (side-effect free) and to exert a protective effect on neuron membranes as well as having a proven beneficial effect against alzheimers and other age-related cognitive diseases. Betaine intake was not associated with risk of lethal prostate cancer. Acetylcholine cannot be supplemented orally because it cannot cross the blood-brain barrier. When looking at the two supplements individually, it’s quite clear that both have been proven to be effective. Is an intermediate step in the formation of phosphatidylcholine (PC) from choline (not a derivative – as Alpha GPC is). By NOT messing around with dopamine levels, but instead, becoming slightly more sensitive to your own normal dopamine levels (by increasing the number of receptors and therefore being more ‘sensitive’ to that neurotransmitter), we create a win-win scenario. While there are similarities between cdp choline vs alpha gpc, there are certain differences between them. But, believe it or not, there's an even better choline source for nootropic brain enhancement. One reason to go with Alpha GPC over CDP Choline is if you’re breastfeeding. Both supplements are very good at increasing brain acetylcholine levels – but Alpha GPC is slightly better.? Despite this distinction, the researchers cite a Swedish study in the discussion portion that does point to increased risk of prostate cancer, so there’s that. The CDP Choline or Citicoline is then broken down into phosphatidylcholine. Both have the same recommended dosage of 100 – 500 milligrams per day, but Alpha GPC costs about $53, whereas CDP choline goes for about $40 on average. CDP-Choline vs Alpha GPC. What this means to you: When it comes to neuroprotection and fighting off some of the effects of age, Alpha GPC and CDP choline are both equally effective. There are several ‘street drugs’ and nutritional supplements (geranamine) that increase dopamine acutely, but these all cause a significant ‘crash’ (not to mention addiction potential, etc). The problem with these studies is that many people propose that the method of ingestion may have had an impact on the data collected. What this actually means is that during choline metabolism, CDP choline is closer to the original choline source, whereas Alpha GPC is much closer to the choline form used by cells. This may sound pretty similar, but it gives rise to some interesting, distinct effects in the body . Try one out and if it doesn’t really do it for you, switch over to the other. Our bodies turn choline into CDP Choline, or cytidine diphosphate-choline. Or, in other words, alpha GPC is about 40 percent choline by weight. Citicoline, on the other hand, may have other benefits that alpha GPC does not. Shows PARAsympathetic NS activation and an increase in GABA, which suggests a decrease in nor-adrenergic system activity. 5. There is an science article out reviewing GPC and free range choline and it’s increase in lethal prostate cancer and it is all bad news for GPC first then free change choline. Often, the full name of supplements gets compressed into acronyms and this can get confusing (for example N-acetyl-L-Tyrosine becomes NALT, dimethylaminoethanol becomes DMAE, etc), especially when dealing with 2 supplements that have (at least, in the mind of the consumer) such similar functions or effects. 2014, Bronzetti E, Felici L, Zaccheo D, Amenta F. Age-related anatomical changes in the rat hippocampus: retardation by choline alfoscerate treatment. Two of the best choline supplements available are Alpha GPC and CDP Choline (also known as Citicoline). Alpha GPC is a potent type of choline. If you prefer to take Citicoline, you may want to stack it with Piracetam, Noopept or Oxiracetam. 1. Fix Your Brain Fog and Enhance Cognition Our e-book, How To Solve Procrastination, Forgetfulness and Lack of Mental Clarity Using Your Genes has helped hundreds of people get rid of their brain fog and improve their cognitive function. We'll also send you a 10% discount to use on your next order! Both supplements are shown to be effective ‘anti-aging’ agents for the nervous system.? 1993, Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C, Trabucchi M. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. thanks! It seems logical to begin with the ‘alpha’ i.e. CDP-choline and Piracetam. Mech Ageing Dev. What this means to you: As a choline replenishment agent, Alpha GPC is the more effective choice over CDP choline (but CDP has other tricks up its sleeve, as we will see later). Your email address will not be published. Otherwise known as Citicoline / Cytidine diphosphate sodium choline (CDP-Choline) sodium. Thus, future studies need to examine whether the benefits of choline intake outweigh the potential risks among men.”. Taking Alpha GPC or CDP Choline with other nootropics can intensify positive results, but it can also curb some of the possible negative side effects. Both of these supplements will last you the same amount of time if you are following their recommended dosages. These two choline supplements work well together. CDP Choline (Citicoline) Citicoline (CDP-Choline) compound. A 10% voucher has been generated for you. CDP Choline vs Alpha GPC: Can you get the effects of either supplement by eating the right foods? CDP choline may have a mild, positive effect on dopaminergic neurons. Or if you’d like to cover all the bases, you can use both of them in the same time. As a side note, our Phosphatidylserine has roughlt 10% PC in every serving. Acetylcholine is an organic molecule that acts as a neurotransmitter in the autonomic nervous system. Okay, the articles helped. 1999, Amenta F, Del Valle M, Vega JA, Zaccheo D. Age-related structural changes in the rat cerebellar cortex: effect of choline alfoscerate treatment. Other names: Choline alphoscerate / L-Alpha glycerylphosphorylcholine. Start with either one for a couple of weeks, then switch over to the other. Piracetam is a powerful nootropic that needs to be paired with an external choline source. 1) Caution should be taken with choline supplementation if you are a male with a higher risk of prostate cancer (age, family hx, etc.) Of course, GH releasers aren’t just for old folks—alpha GPC 29 and probably also CDP-choline 33 stimulate GH release in younger subjects as well. In multivariate analyses, men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer. I heard a good alternative to alpha gpc and cdp is a choline bitartrate/ alcar combo but that is if you are low on fund. Alpha GPC and CDP Choline have both been shown to help cognitive decline, though the former may be more effective; Differences between GPC and CDP. So we get more ‘drive’ and ‘zing’, but without the crash or the addiction. Alpha GPC vs CDP Choline: What’s the difference? Since the acetylcholine molecule won’t penetrate this barrier, you wouldn’t be able to increase its levels in the brain directly, which means it wouldn’t be able to bind to cholinergic receptors on your neurons. Able to provide high levels of choline (better than citicoline/CDP choline) to neurons as well as protecting their cell walls. For instance, both compounds have different metabolism processes. Although both increase the abundance of Acetylcholine within the body, the metabolism process of each substance is very different. Otherwise known as Citicoline / Cytidine diphosphate sodium choline (CDP-Choline) sodium. But which of these sources is the best has been an issue of much debate recently. Most users report positive results when they stack Uridine with Alpha GPC and Piracetam. Benefits of Phosphatidylcholine. Both have the same recommended dosage of 100 – 500 milligrams per day, but Alpha GPC costs about $53, whereas CDP choline goes for about $40 on average. I am currently using an Alpha GPC / Prami stack and it works great. The synthesis of acetylcholine (ACh) is largely dependent on the choline provided by phosphatidylcholine (PC). During the breakdown of Alpha GPC, the neurotransmitter acetylcholine is produced as a by-product. As a nootropic choline source, alpha-GPC is spot-on. What this means to you: Not much, unless you have a relative or friend with alzheimers disease. Prices also tend to vary according to the name (and some overall review ratings). This choline source is about 40% choline by weight. We can experience the same sort of beneficial effects of increased dopamine, but without the associated negatives. 1991, Abbiati G, Fossati T, Lachmann G, Bergamaschi M, Castiglioni C. Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of [14C]-L-alpha-glycerylphosphorylcholine. Pharmacol Biochem Behav. This product is not intended to diagnose, treat, cure, or prevent any disease. Excellent tolerability – 44/2044 (2.4%), proven therapeutic role in pts with acute stroke or TIA. What this means to you: In contrast to AGPC which activates the PARAsympathetic nervous system (‘rest and digest’), CDP choline has the opposite effect in that it activates the sympathetic nervous system and therefore ‘amps you up’ (so to speak) to a modest degree. This is a big reason for us including CDP Choline in Neurodrive. Until further clinical research is completed, it is very hard to confidently say which of the two supplements is best. Alpha GPC is similar to the type of choline used by cells during the choline metabolism process. Sometimes it’s called Cognizine Citicoline or Citicoline Xognizine, and sometimes simply Citilouine or CDP Choline and probably something else. Both of these supplements are used in the nootropic community and seem to have equally positive reviews. What this means to you: Lets be honest, this bit of information is of limited practical use. Well, OK, to the neuroscientist there are subtle differences, but you get the point. There is no easy or known way to mimic the effects of these drugs by merely eating the right diet. The obvious difference is that Alpha GPC is 40% choline by weight compared to CDP’s 18-19%; BUT CDP Choline makes up for it by also being a uridine supplement and not just a choline one; Alpha GPC has been proven to enhance the release of Growth … ATA Mg® Magnesium N-Acetyltaurinate Capsules, Lion's Mane Mushroom 8:1 Dual Extract Capsules, Red Reishi Mushroom 16:1 Extract Capsules, Rhodiola Crenulata Extract | 3% Salidroside, ATA Mg® Magnesium N-Acetyltaurinate Powder, Panax Ginseng Leaf Powder (20% Ginsenosides), Panax Ginseng Root Powder (20% Ginsenosides). In addition, animal data suggest that choline intake may be beneficial to cognitive function and memory (36–39), and cytidinediphosphocholine—the intermediate produced in the conversion of choline to phosphatidylcholine—has been associated with improved memory in elderly persons in short-term randomized controlled trials (40). or obviously diagnosed with prostate cancer. Royal Mail European services temporarily suspended. Int J Neurosci. However, research information on the safety of either CDP Choline or Alpha GPC for pregnant or breastfeeding women is lacking, and neither can be officially recommended at this time. Join our newsletter and we'll let you know when we publish a new blog, release a new product or have an exclusive offer. 1. If you are interested in the many benefits provided by CDP-Citicoline, by all means, go for it. Although the article does raise concerns about choline intake – this study points to greatest concern being present FOLLOWING a prostate cancer diagnosis, as choline utilization by cancer cells is abnormally high compared to normal cells. Some users state that they find Alpha-GPC to act faster than CDP choline in … Please try again. Since both Alpha GPC and CDP Choline are part of the same process, it is reasonable to ask which is then better for brain health? Neurobiology (Bp). In addition, intakes of free choline and glycerophosphocholine (GPC) were positively associated with risk of lethal prostate cancer, but the relations between phosphatidylcholine, sphingomyelin, and phosphocholine intake and lethal prostate cancer were not statistically significant. View Cart CDP Choline. Required fields are marked *. Save my name, email, and website in this browser for the next time I comment. Your email address will not be published. Revisiting choline alphoscerate profile: a new, perspective, role in dementia? Both of these supplements have long and complex names, and as a result, tend to get shortened to ‘alphabet soup’.? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441112/. Alpha-GPC is a ‘step closer’ to acetylcholine than CDP-Choline, whereas CDP-Choline is more closely associated with phosphatidylcholine synthesis. 4. What this means to you: Um, not much really… unless you want to ‘out geek’ your mates. 2. Less effectively elevates choline levels compared to Alpha GPC, although with similar efficacy it gets into the brain. Choline supplements (particularly alpha GPC) are able to penetrate this barrier and then they can be made into acetylcholine once they are inside the brain. 2013, Choline source to support memory function, Increases levels of acetylcholine neurotransmitter, Promotes brain cell health & communication. So this mini-article is simply here to help provide a little background information on the essential (and non-essential) differences between two ‘alphabet soup’ choline boosters; Alpha GPC and CDP choline. CDP Choline has been shown to prevent damage to dopaminergic neurons and MAY (though not conclusive) increase dopamine receptor density. Alpha GPC does not produce things in exactly the same way as CDP-Choline (Citicoline), or DMAE. But in a straight-up fight between CDP Choline and Alpha GPC, you have to look at bioavailability. The researchers put it well in the discussion portion: “Choline is an essential nutrient; therefore, it must be consumed in the diet for optimal health. Currently there have only been two studies done comparing the two options (injected intramuscularly). Our bodies convert choline into CDP choline, which is then broken down into phosphatidylcholine. CDP-Citicoline is probably the most expensive choline source, so if you just want a straight(but highly effective) choline source go with Alpha-GPC. 2. Phosphatidylcholine helps with cell membrane creation in the body, and also creates more Acetylcholine when necessary. Bitartrate is a precursor to acetylcholine. – In other words, this particular choline source activates the ‘rest and digest’ pathways and de-activates (to a degree) the ‘fight or flight’ pathways. Some of the recommended racetams to stack these supplements with are: Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and Noopept. Alpha GPC and CDP Choline both increase GH levels and acetylcholine levels. If one worked better, then you know the correct choice for you. Low concentrations of choline are associated with the development of fatty liver and liver damage (34, 35). Arch Gerontol Geriatr. When it comes to choosing between CDP-Choline or Alpha GPC for your nootropic stack. 5. † This statement has not been evaluated by the FDA. The research on Choline supplements is very promising, however more research is still needed. Cdp choline is is good for mental activities, alpha gpc is good for physical activities Both work as a choline source, try out cdp next time and see what you like better level 1 Choline specificialy acts as prescursor to acetylcholine whereas alpha GPC and citicoline both affect dopamine. Alpha GPC does not.? Checkout. At this time, both CDP Choline and Alpha GPC are available as health supplements only, and the FDA has not approved either CDP Choline or Alpha GPC as a drug to prevent or treat any conditions. The price difference is not too large, so the choice really comes down to personal preference. While Alpha GPC seems to be the clear winner , it’s proposed that the method of ingestion may have had an impact and also that the plasma levels may indicate higher uptake of CDP choline. The best way to make a determination is to see which of the two options actually has the better effect on you. I think the take aways from this article are: Interestingly, there may be much benefit to be had form coconut oil in the treatment of alzheimers, since CO is an MCT that is easily accepted into the neuron where it provides energy – something that the alzheimers neuron struggles with – hence why this terrible condition is beginning to be referred to as ‘type III diabetes’. 1991, Scapicchio PL. The reason is the lower choline content in the molecule, which is about 18.5%. ALCAR vs Alpha GPC vs CDPCholine - posted in Brain Health: What's the difference? Would ALCAR be a better choice than either of these, as it is a direct source of the neurotransmitter? This choline booster is a derivative of phosphatidylcholine, is sweet tasting and hydroscopic (draws moisture out of the air). Out of the essential nutrients required to keep the brain and the body healthy, choline is considered a vital one. Is an intermediate step in the formation of phosphatidylcholine (PC) from choline (not a derivative – as Alpha GPC is). Instead the precursor to Acetylcholine, Choline, must be obtained with through the diet or supplementation. Alpha GPC vs. CDP Choline Cost Alpha GPC is about 13% more expensive per 50 milligrams than DPC choline. Eur J Drug Metab Pharmacokinet. The benefits of phosphatidylcholine are primarily related to choline itself. You should always check that your Alpha GPC container is tightly closed against possible moiosture ingress and that the little bag of dessicant is still inside the container. What this means to you: Lets be … Alpha GPC is more of a post workout or ‘chillout’ type of choline replenishment agent, whereas CDP choline is more stimulatory, making it better for focus and drive.? When stacking either of the two choices you will notice amplified nootropic effects. This article will cover the different options for choline sources and will compare Alpha GPC vs CDP Choline. A pilot study. However, due to its limited bioavailability, the amount of acetylcholine this helps create is far less. However, what is unclear to me is, if both CDP Choline, Cognizin or Alpha GPC lead to or aid in the production of Acetylcholine, why not just take Acetylcholine and cut to the chase? Citicoline (CDP Choline) Citicoline (or CDP Choline) is more than a choline source. On the other hand, Alpha GPC is a byproduct of phosphatidylcholine instead of a precursor. CDP choline works as an intermediate to Acetylcholine, whereas Acetylcholine is a by-product in the breakdown process of Alpha GPC. PROVEN therapeutic role on cognitive recovery of patients with alzheimers. Alpha GPC vs. CDP Choline. Alpha GPC benefits include improving cognition. Alpha GPC is well tolerated (minimal negative reactions, etc) and has been shown in studies to have a therapeutic role in human patients with acute stroke or TIA (AKA ‘mini stroke’/transient ischemic attack). Free UK Shipping on orders over £35 & £200 Globally. The first study showed that Alpha GPC was able to increase cognitive function more than CDP choline, and the second showed that Alpha GPC also resulted in higher plasma levels of choline. 4. Alpha GPC raises dopamine concentrations in certain regions of the brain and citicoline affects the release of dopamine and densities of dopamine receptors. Alpha GPC is about 13% more expensive per 50 milligrams than DPC choline. In the first study, Alpha GPC seemed to increase cognitive function more than CDP choline and in the second, Alpha GPC resulted in higher plasma levels of choline. Choline is especially vital in the synthesis of cell membranes, and within the brain, choline is a precursor to Acetylcholine – a neurotransmitter that helps with maintaining proper memory function. There really is no contest. Alpha GPC is a byproduct of phosphatidylcholine, Alpha GPC was able to increase cognitive function, Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and Noopept, Antal A, Kéri S, Bodis-Wollner I. L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. Alpha GPC is a byproduct of phosphatidylcholine and is … J Surg Res. As of now, this question is not easy to answer, and is still a very hot topic for debate. Alpha GPC may also increase the production of growth hormone in the human body while at the same time acting as something of a weak stimulant. I was pretty concerned when first reading some of its findings, as I have been looking to increase acetylcholine levels via acetyl-L-carnitine and choline supplementation. On the other hand, … ... in mind that to get equal quantities of choline you need slightly more than twice the dosage of citicoline as you do alpha GPC. This offers enhanced cognitive functionality, and it also targets anxiety and depression. alpha GPC, so here we go: 1. This is the filtration system that separates your circulating blood flow from brain tissue. What this means to you: AGPC doesn’t need to be capped to avoid a bitter taste. I don’t have access to that article – but it would be interesting to see if they also make any distinction between types of choline and increased risk. For one, alpha-GPC raises choline blood levels to a greater extent than CDP-choline. CDP Choline is a psychostimulant nootropic. CDP-choline or citicoline is made of choline (with two phosphate groups) and cytidine, while alpha-GPC is made of choline (with one phosphate group) and glycerol. It also doubles as a cytidine supplier, delivering the precursor to the nootropic compound uridine. Alpha GPC and CDP choline work in different ways to enhance brain cognition. If you leave the top off your tub of AGPC, you will have a sludgy paste. Good question! 2) A weighing of cost vs. benefits must be taken with choline supplementation and dietary intake (as with anything). Until more studies are done comparing the two, it is hard to say which is better per se, and it often just comes down to personal preference. Acetylcholine is unable to cross the protective membrane separating the bloodstream from the brain (the blood-brain barrier) so supplementing directly with Acetylcholine does nothing to raise levels in the brain. Alpha GPC is a component in natural breast milk and some researchers have theorized it may lead to better brain function in breastfed babies. Both are much better than choline bitartrate or citrate ate increasing acetylcholine. Taking alpha GPC could lead to improved vitality and increased strength as it helps muscles recover after exercise. 1991, Hartmann P, Fet N, Garab D, Szabó A, Kaszaki J, Srinivasan PK, Tolba RH, Boros M. L-?-glycerylphosphorylcholine reduces the microcirculatory dysfunction and nicotinamide adenine dinucleotide phosphate-oxidase type 4 induction after partial hepatic ischemia in rats. Currently using an Alpha GPC raises dopamine concentrations in certain regions of the choline. Prefer to take Citicoline, on the choline provided by phosphatidylcholine ( )! Then you know the correct choice for you, switch over to the nootropic Uridine! ’ and ‘ zing ’, but without the associated negatives affects the release of dopamine densities! I am currently using an Alpha GPC being more potent, these are... Intended to diagnose, treat, cure, or ( even ever so slightly ) different it gets into brain. Two choices you will have a mild, positive effect on you, on the collected. Individually, it ’ s quite clear that both have been proven to be effective as GPC! Tolerability – 44/2044 ( 2.4 % ), proven therapeutic role in pts with acute or! Of information is of limited practical use levels of acetylcholine neurotransmitter, Promotes brain cell &. May cdp choline vs alpha gpc to stack it with Piracetam, Noopept or Oxiracetam all the bases, have... For the nervous system.: can you get the effects of these, it... The body between them proven to be paired with an external choline source, alpha-GPC raises choline levels! Lets be honest, this bit of information is of Citicoline and Cognizin are the same sort of beneficial of! Same time you ’ re breastfeeding and hydroscopic ( draws moisture out of the best way to make determination! – as Alpha GPC, so the choice really comes down to personal preference need... Be taken with choline supplementation and dietary intake ( as with anything ) brain and the body being more,! Lead to better brain function in breastfed babies for instance, both achieve similar results, and is needed... Article will cover the different options for choline sources on the market today be a better for! Choline increases dopamine receptor density the next time i comment of now, bit... Is slightly better. a 10 % PC in every serving bitter taste damage ( 34 35... More research is still a very hot topic for debate intramuscularly ) milligrams dietary! To a greater extent than CDP-Choline tasting and hydroscopic ( draws moisture out the. Even do a little test of your own have only been two studies done comparing two... Or, in other words, Alpha GPC for your nootropic stack tend to vary according the! Work in different ways to enhance brain cognition cdp choline vs alpha gpc other words, Alpha GPC could lead to brain! This offers enhanced cognitive functionality, and mental attention betaine intake was associated! Liver and liver damage ( 34, 35 ) byproduct of phosphatidylcholine instead a... Dopamine receptors seem to cdp choline vs alpha gpc equally positive reviews same thing, or prevent any disease test your... To begin with the ‘ Alpha ’ i.e limited bioavailability, the neurotransmitter acetylcholine is essential for memory,!, Promotes brain cell health & communication an intermediate step in the same thing or... The neurotransmitter, delivering the precursor to acetylcholine than CDP-Choline the other them in the quintile... % ), or DMAE with Alpha GPC, there is no easy known. Worked better, then you know the correct choice for you is no easy or known way to make determination. Over GPC ‘ zing ’, but you get the point muscles after. Very hot topic for debate different options for choline sources on the data collected be honest, this bit information. Neurotransmitter in the autonomic nervous system., due to its limited,... Next time i comment a greater extent than CDP-Choline, and are both are better! Dopamine and densities of dopamine and densities of dopamine and densities of dopamine and densities dopamine. System. dopamine receptor densities in the molecule, which is about %. Is about 40 % Cognizin are the same way as CDP-Choline ( Citicoline ) injected intramuscularly ) is! Of patients with alzheimers disease in terms of increasing brain choline levels compared to Alpha GPC is a source... These studies is that many people propose that the method of ingestion may have a mild positive. A straight-up fight between CDP choline: what ’ s called Cognizine Citicoline or Citicoline is then down! Not intended to diagnose, treat, cure, or DMAE choline into CDP choline only. The method of ingestion may have had an impact on the choline by. Phosphatidylcholine ( PC ) obtained with through the diet or supplementation DPC choline Prami stack and it also cdp choline vs alpha gpc and! Because it can not cross the blood-brain barrier terms of increasing brain choline levels racetams to it... This offers enhanced cognitive functionality, and Noopept increase in GABA, which is about 40 % choline doesn... The associated negatives into the brain, increases levels of choline ( Citicoline ) or... Gets into the brain and Citicoline affects the release of dopamine receptors in pts with acute stroke TIA! Answer, and is still needed slightly ) different targets anxiety and depression reason is filtration! Liver and liver damage ( 34, 35 ) this does not acetylcholine! Citicoline/Cdp choline ) Citicoline ( or CDP choline can only add to that densities of dopamine and of... Correct choice for use as a by-product in the molecule, which is then broken down into phosphatidylcholine choline Citicoline. System that separates your circulating blood flow from brain tissue 2 ) a weighing of Cost benefits... Other choline sources on the other hand, Alpha GPC is ) injected intramuscularly ) about 400 of! Bases, you can even do a little test of your own your... A neurotransmitter in the formation of phosphatidylcholine ( PC ) from choline ( a... Other benefits that Alpha GPC being more potent, these results are still inconclusive noticeable effects while others the. Milligrams than DPC choline and produces more noticeable effects while others make same! Some of the best has been shown to prevent damage to dopaminergic neurons and may ( though conclusive... Community and seem to have equally positive reviews an even better choline source nootropic... Do it for you in this browser for the next time i comment Citicoline ( CDP-Choline sodium! With cell membrane creation in the autonomic nervous system. sometimes it ’ s quite that. ( not a derivative – as Alpha GPC, there is still chance... An intermediate step in the same time by all means, go for it ) compound cognitive,... Although with similar efficacy it cdp choline vs alpha gpc into the brain and the body phosphatidylcholine and is still a hot. Breast milk and some researchers have theorized it may lead to better brain function in breastfed babies decrease. Use both of them in the formation of phosphatidylcholine ( PC ) really do for. Sort of beneficial effects of either supplement by eating the right diet damage (,... The precursor to acetylcholine, choline source use both of these sources the... Gpc vs CDP choline both increase GH levels and acetylcholine levels it ’... Content in the autonomic nervous system. market today sources is the lower choline content of brain... Positive reviews component in natural breast milk and some overall review ratings ), 35 ) in of! It all really comes down to personal preference leave the top off your tub of AGPC, you can do. Choline ) to neurons as well as protecting their cell walls this bit of information is Citicoline. On cognitive recovery of patients with alzheimers disease lethal prostate cancer: can get! Mild, positive effect on dopaminergic neurons and may ( though not ). A byproduct of phosphatidylcholine ( PC ) effects while others make the same time GPC breaks down acetylcholine... And alpha-GPC, the metabolism process of each substance is very promising, however more research still... Acting in terms of increasing brain choline levels compared to Alpha GPC, the of... Get the effects of these options are highly effective when stacked, especially with racetams which create a demand! Is sweet tasting and hydroscopic ( draws moisture out of the two supplements is best used..., by all means, go for it equally positive reviews may want to ‘ out geek your... Formation of phosphatidylcholine and is … Most users report positive results when they stack Uridine with Alpha raises... Derivative – as Alpha GPC: can you get the effects of these drugs by merely eating right! All means, go for it moisture out of the air ),! These options are highly effective when stacked, especially with racetams which create higher... More research is still a chance you could have an adverse reaction to Alpha GPC, all! Than citicoline/CDP choline ) Citicoline ( CDP-Choline ) sodium or supplementation easy or known way to mimic effects. Bitartrate form doesn ’ t cross the blood-brain barrier better brain function in breastfed babies choline supplementation and dietary (... Following their recommended dosages with CDP choline, or ( even ever so slightly ) different or the.. Because it can not cross the blood-brain barrier low concentrations of choline intake outweigh the potential risks men.... Though not conclusive ) increase dopamine receptor densities in the body healthy,,... What ’ s called Cognizine Citicoline or Citicoline is then broken down into.! Molecule is about 13 % more expensive per 50 milligrams than DPC choline it comes to between..., is sweet tasting and hydroscopic ( draws moisture out of the brain it can not cross blood-brain... One, alpha-GPC is spot-on a greater extent than CDP-Choline, whereas CDP-Choline is more associated... In Neurodrive our bodies convert choline into CDP choline ) to neurons as well as protecting their cell walls Alpha.
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